NKR Living Donor Evaluation Guidelines
The purpose of the evaluation and consent of the living donor is to maintain the highest
degree of safety and transparency for the living donor. As a baseline, the
Amsterdam Guidelines and the OPTN standards will be used for donor evaluations. Donor evaluations
must be completed before a donor can be activated in the NKR.
The donor center evaluation policies should be followed by the donor center and not be
directed by the recipient center since the donor center is responsible for donor care. The
receiving center may ask for additional testing to clarify issues related to the quality of
the kidney or to ensure there is minimal risk of infectious disease transmission. Requests
for additional donor testing should be made immediately upon cross commencement in order to
avoid late stage donor declines and failed swaps.
- Complete history and physical
- Height, weight, BMI
- BP at two different settings on different days
- General laboratory to assess:
- hematologic status,
- fasting lipids and glucose
- liver status
- Age appropriate evaluation for cancer
- Donor work-ups must be repeated in their entirety, every 12 months, except for CT angio, unless the first CT angio was abnormal
- Urinalysis with microscopy
- Urine culture if indicated
- 24 hour urine for albumin excretion and creatinine clearance
- Anatomic Testing for anatomy definition
- If a donor GFR reading comes in at or below 85, the center will perform a nuclear medical GFR test to confirm the donor's GFR is > 80
- If there is > 10% difference in donor kidney size (between the two kidneys) then the smaller kidney will be offered for donation
Infectious disease screening:
- HIV 1,2
- HBsAg, HBcAB, HBsAB
- Depending upon time of year and location associated risk
- Trypanosoma cruzi
- West Nile Virus
Suggested evaluation for donors at risk for metabolic syndrome or diabetes:
- Uric acid
- Glucose tolerance testing
- If multiple stones or nephrocalcinosis are not evident on CT, an asymptomatic potential donor with history of a single stone may be suitable for kidney donation if they have:
- No hypercalcuria, hyperuricemia, or metabolic acidosis
- No cystinuria, or hyperoxaluria
- No urinary tract infection
- An asymptomatic potential donor with a current single stone may be suitable if:
- The donor meets the criteria shown previously for single stone formers
- The current stone is less than 1.5 cm in size, or potentially removable during the transplant
- Stone formers who should not donate are those with:
- Nephrocalcinosis on x ray or bilateral stone disease
- Stone types with high recurrence rates, and are difficult to prevent
Good Samaritan Donor Guidelines
A Good Samaritan Donor is also known as a Non Directed Donor (NDD). They are donors that
want to donate to a stranger and may want to start a chain of transplants.
Guidelines for Member Centers working with Non Directed Donors are as follows:
- NDD's should be made aware of their donation options. They can either start a chain
of transplants or donate to a single recipient on the centers waitlist.
- If an NDD donates to someone on the center's wait list, the scheduling of
surgery may be easier for the NDD.
- If an NDD starts a chain of transplants, they will generally help more
- It often requires a long wait time for "AB" blood type NDD's to start a
- Member Centers should advise NDDs that NKR will provide donor insurance if they
start a chain through the NKR.
- It is the responsibility of the Member Center to educate the NDD. Member Centers
should fully explain the donation process to the donor and should let them know what
to expect, before, during and after surgery.
- Member Centers should ensure that the NDD can get appropriate time off from work.
- Member Centers should determine the NDD's availability for surgery and accurately
enter it into the NKR system.
- Member Centers should ensure the NDD is updated on a timely basis regarding where
they are in the workup process, results of all medical tests, when they are
activated in the NKR program and the status of chains that the NDD is facilitating.
- The Member Center should inform the NDD that there may be financial support
available to assist them in the donation process if they qualify. Eligibility
guidelines can be found by clicking on the link to the National Living Donor
Assistance Center website.
Medical Board Policies
Match Offer Selection Policy
The NKR shall select match offers based on the following scientific and objective criteria:
Policy For Ending Chains
- When adequate time is available, match offers shall be selected to facilitate the most
possible transplants (i.e. longest string of loops and chains)
except when a difficult to match pair can be matched.
- When time is limited (e.g. NDD has an aggressive donation deadline, compatible pairs
are involved in a swap, etc.), match offers with the greatest probability to make it
to transplant within the allotted timeframe, shall be selected (e.g. donors
pre-selected, donors worked-up, cross matches completed, Member Center surgeons are
available, coordinators are available, etc.)
- When multiple potential match offers yield equal numbers of transplants, the hardest
to match pairs will be prioritized based on pair match power. If pair match power is
equal, the longest patient wait times in the NKR system will be given priority.
- When multiple CHIPs can end the same chain, children will be given priority. Secondary
priority shall be determined by the patient's difficulty to match based on recipient
The NKR shall end chains according to the following priorities:
Children & High PRA (CHIP) Program
- To former NKR Non-Directed Donors (NDDs) in need of a kidney transplant.
- To a recipient whose donor has donated and the recipient does not have a kidney such as when an intended donor becomes ill, an out of sequence swap is executed or when advance donation with informed consent takes place.
- To CHIP candidates. The center receiving the kidney shall be determined based on forecasted net chains started (FNCS) with the objective of managing FNCS by center within a range of -1 to +3. For the purpose of calculating FNCS, the Member Center that completes the NDD work-up is the center that receives credit for starting a chain.
The CHIP program helps patients without donors who are either children or are disadvantaged because they are sensitized:
- Member Centers may enroll up to 50 candidates in the CHIP program.
- CHIP candidates are patients without donors including children (18 or younger) or sensitized adults.
- The most likely blood type to find a CHIP match is an "AB" patient, followed by "A" and "B" blood type patients.
Donor Center (providing donor workup and/or nephrectomy) and Recipient Center (performing
recipient transplant) desire to provide paired exchange services and agree to the following:
- General: In all cases the donor shall not be billed for transplant related medical
services including donation evaluation, in-patient stay for donation and post donation
complications per Medicare standards. All claims must be submitted to the Recipient
Center within 120 days from the last day of service. Acknowledgement is due upon receipt
of claims. Claims payment is due as soon as possible and no later than 90 days from the
receipt of an accurate claim.
- Pre-Transplant Donor Evaluation Services: The Donor Center shall provide pre-transplant
donor evaluation services. The Donor Center shall allocate all costs for the donor
evaluation to their Medicare cost report. Physicians participating in the donor
evaluation shall bill the Donor Center.
- Kidney Shipping and Logistics Support: Transportation of the donor organ to the
Recipient Center shall be coordinated by the NKR who shall bill the Recipient Center for
the costs associated with kidney shipping and logistics support. All OPO costs
associated with packaging, labeling and perfusion services shall be billed to the Donor
Center. The Donor Center shall pass these OPO costs along to the Recipient Center for
- Recipient Inpatient Services: The Recipient Center shall bill for services as customary
by submitting claims to the recipient's insurance. The physicians shall bill the
recipient's insurance for services rendered.
- Donor Complications: Donor complications that arise after the donor's discharge will be
billed as follows:
- If Medicare is primary, then both physician and hospital services shall be
billed under the recipient's health insurance claim number to recipient's
- If there is a global arrangement, then both physician and hospital services
shall be billed to the Recipient Center.
- If Medicare is not primary and there is not a global arrangement; then both
physician and hospital services shall be billed to the recipient's insurance.
- Hospital Donor Nephrectomy: The Donor Center shall bill the Recipient Center for the
donor organ recovery cost by providing a copy of their most recently filed Medicare Cost
Report, Worksheet D-6, Part I, which documents the cost per day and the appropriate cost
to charge ratios along with a worksheet that reduces the Donor Center bill from charges
to cost. (sample worksheet)
- Physician Donor Nephrectomy: Physicians shall bill the Recipient Center or recipient's
insurance for services rendered according to the following:
- If Medicare is primary, physicians shall bill Medicare utilizing the recipient's
- If the Recipient Center has a global arrangement, the donor physicians shall
bill the Recipient Center at 150% of Medicare participating. Anesthesiology
shall bill at $65.29/ASA unit.
- If Medicare is not primary and if there is not a global arrangement, then the
Recipient Center will work with the Donor Center to ensure the donor physicians
get paid appropriately.
- Regulatory Compliance: This agreement shall serve as written evidence of the required
agreement between the Donor Center outlining the scope of services and the process to 1)
review the policies and procedures related to: donor evaluation and selection, informed
consent, and multidisciplinary donor management throughout the phases of donation; and
2) to monitor and evaluate these services.
- Additionally, the Donor Center agrees to:
- Utilize the NKR standard swap checklists posted on the NKR web site to
ensure regulatory compliance
- Provide the recipient center with copies of living donor medical records
up to the point of donation
- Enter swap process issues into the NKR system where appropriate
- Immediately communicate to NKR if the Member Center is no longer in good standing
- Additionally, the Recipient Center agrees to:
- Utilize the NKR standard swap checklists posted on the web site to ensure regulatory compliance
- Immediately communicate to NKR if the Member Center is no longer in good standing
- Enter swap process issues into the NKR system where appropriate
HLA & Cross Matching
Accurate tissue typing and cross matching are critical to the success of our program. To
minimize unexpected cross match failures, all member center labs have agreed to:
- Accurately enter donor antigens and recipient antibodies including: A, B, DR, Bw, Cw, DQ, DP, DQa, DR-51, DR-52, DR-53
- Update recipient antibodies every 90 days or whenever they change
- Engage experienced Lab personnel to review all match offers with the goal of achieving a
100% virtual cross match accuracy rate
- Report results for the final cross match at least 7 calendar days prior to the scheduled
- If a center reports an unacceptable cross match or virtual cross match failure:
- email the root cause and corrective action to NKR within 48 hours
- review the root cause and corrective action on the National Lab Director call
- Member Centers are strongly encouraged to cryopreserve donor cells in order to minimize
donor blood draws and to be able to react quickly to a false positive results by
rerunning the cross test using cryopreserved samples
- In order to ensure a streamlined process for cross matching, the following procedures
- Donor center draws and ships donor blood to the recipient center/lab
- The recipient center is not permitted any contact with donor
- Donor blood tubes that are shipped to the recipient center include donor name,
date of birth, social security number, date specimen drawn and initials of
technician drawing the blood
- Donor center notifies recipient center when to expect blood and provides the
package tracking number
**NKR Pick and Ship Kit process is a future offering. Centers shall continue to provide test
kits for cross matching until this service is available from NKR.
Preparation for shipping living donor kidneys:
- Donor center will send tubes requested by recipient center for confirmatory donor
ABO, initial crossmatch and final crossmatch
- Donor center must register the donor and obtain a UNOS donor ID number
Packaging supplies include:
- Organ box
- Red biohazard bag inside organ box
- Clear plastic bag with ice inside a Styrofoam container
- Triple barrier packaged kidney (one of which is jar) – all sterile
- Labeling attached to kidney bag and outside of box with UNOS ID, ABO and Contents
Kidney box must include the following:
- A UNOS label filled out according to UNOS standards on the outside of the box
- NKR supplied GPS Device (if required by logistics plan)
- NKR supplied Human Organ stickers (if GPS is used) affixed to all 6 sides the box before
other labels are applied so that other labels are fully visible
- Destination mailing address on the outside of the box (recipient center)
- Return address on the outside of the box (donor center)
- Two ABO verifications each for donor and recipient (if ABO on crossmatch that may
considered as first ABO for donor and recipient)
- Crossmatch result of the donor and recipient
- Kidney anatomy (aka Renal Data Sheet)
- Name and DOB of Recipient
- Teidi Donor Registration Page: Please 'print screen' this page (page displays Donor
Name, DOB, Donor UNOS ID Number)
- Donor blood tubes per recipient center request
- Copy of the completed NKR packaging checklist
Shipped Kidneys and GPS Tracking
- Donor Centers will receive a GPS device, if required, from NKR approximately 1-5
business days before donor surgery. The device will be charged and requires no
- The GPS device must be packed with the kidney. The device is in a water-proof bag which
can be left on top of the ice or inserted between the shipping containers.
- Coordinators at both the donor and recipient centers will receive periodic alerts to
their cell phone and Email, giving the location of the GPS beacon. The device will give
a N/A reading once airborne at an altitude of approximately 5,000 feet and higher, it
will take approximately 30 minutes after take-off to give the N/A reading.
- The coordinator must contact the swap manager immediately if there are any
inconsistencies between the GPS readings and logistics plan.
- Recipient Centers will receive pre-paid return packaging from NKR for the return of the
- The GPS device must be sent back to NKR no later than one business day after recipient
- It is the responsibility of the coordinators of the recipient center to monitor the GPS
device; In addition to periodic alerts the device can be tracked via the internet,
instructions on accessing the GPS tracking website are listed below.
- Contact your NKR liaison to acquire user name and password.
- Click the following link:
- Enter the username and password you were given and click login.
- On the right side of the screen highlight the device you are looking to locate,
they are listed under "Map View", once highlighted click "show selected" button.
- To view in Google Earth wait for map to open and in top right of map click
"Export to Google Earth Format".
Member Center Requirements
- Centers shall follow all instructions, procedures and policies listed on the NKR web
site and included in NKR emails
- Centers shall share all relevant information to ensure the best possible outcomes for
all swap participants
- Centers shall act with the utmost spirit of cooperation to achieve the greatest number
of successful transplants across all member centers
- Centers shall ensure all information entered into the NKR web site is updated and
- Centers shall ensure swap participants are ready to go to surgery once they are
activated in the NKR system
- Centers shall enter accurate post-transplant data so that research can be conducted on
- Centers shall respond to match offers by the match offer deadline which is generally
within one business day
- When a match offer is accepted, the pair must be immediately deactivated in all other
exchange programs, including internal programs
- When a match offer is accepted, the recipient's chart must be reviewed for updates and
creatinine must be immediately rechecked for predialysis patients
- Member Centers shall communicate to all donors that the expected turn-around time for a
blood draw request is 1-2 business days.
- Donor centers shall notify donors immediately when a blood draw is requested so that
donor blood can be shipped overnight to the recipient center within 1-3 business days of
- Recipient centers shall report cross match results 1 business day after receipt of donor
- If a donor is travelling internationally or expects to be unavailable for blood draws
for a period of a week or more, they must be deactivated in the NKR system until they
are once again available for a blood draw.
- Member Centers must not contact another center's donor, recipient or lab for any
- When cross matching commences, donor medical records shall be immediately shared with
the recipient center. If the recipient center needs CTA film, the recipient center will
request the film within 24 hours of the commence XM notification
- Centers are encouraged to place recipients on hold for deceased donor transplants, once
cross matching is successfully completed
- Donor pre-operative lab studies (CMP, CBC, UA, C&S) must be completed at least 2 weeks
prior to the surgery date to insure donor can proceed
- All donors must have two ABO typings, including sub typing where appropriate, before
they are activated in the NKR system
- Centers shall review potential donors via the Donor Pre-Select function so that the %
reviewed is always 95% or higher
- Centers shall update the online NKR required fields so that the Data Compliance score is
always 99% or higher
- Centers shall request an exploratory cross match if there is a reasonable chance of an
unacceptable cross match with a potential donor
- If a center experiences an issue that is reported in the cross match failure report,
they will attend the National Lab Director call to review the issue
- Centers shall provide the NKR, upon request, a root cause and corrective action plan
within one week of the request
- Centers shall conduct antibody screenings every 90 days for sensitized patients enrolled
in the NKR and update the avoids appropriately
- When a center requests information using the “REQUEST DONOR INFO” feature, the donor
center must enter the requested information into the donor profile and notify the
requesting center that the requested information has been added to the donor profile
within 24 hours of receipt of the request. This will avoid additional future requests by
other centers seeking the same donor information.
- Primary and backup coordinators must be identified with cell numbers entered on the web
- Primary or backup coordinators must be available 24x7 the day before, and the day of a
- Primary or backup coordinators at the recipient center are required to monitor the
GPS beacon as outlined in the Shipped Kidneys and GPS Tracking section.
- Primary or backup coordinators must respond same day (email or phone) during regular
- If a pair becomes unavailable to participate in a swap (e.g. recipient sick), that pair
must be immediately deactivated in the NKR system
If after the kickoff call the Exchange Coordinator becomes aware of a situation that
puts the swap at risk he/she must immediately send an email to Member Services with
notification of the situations and that they will contact the Swap Manager.
The Exchange Coordinator will contact the Swap Manager via phone alerting him of the
situation. If the Swap Manager cannot be reached via phone the Exchange Coordinator will
alert their Center Liaison or any member of the NKR staff.
- Primary or backup coordinators must be available for conference calls (e.g. logistic
calls, kickoff calls, etc.) with one business day advance notice.
- The NKR standard donor antigens and recipient antibodies listed on the NKR web site must
be accurately entered for swap participants
- Experienced Lab personnel must review all match offers with the goal to achieve 100%
virtual cross match accuracy
- If a center fails a live or virtual cross match, the root cause and corrective action must
presented by the lab director on the National Lab Director call
- Every A blood type donor must be sub-typed for A1 and non-A1 status
- Centers shall use the standard financial model posted on the NKR web site to facilitate
cost reimbursement between centers
- Centers shall not withdraw from an exchange for financial reasons after the cross match
tests are successfully completed
Centers shall maintain an updated contract with NKR
- Must speak directly with the other surgeon(s) in the swap prior to, and after surgery,
to communicate anatomy and other relevant medical issues
- Must be ready to schedule the OR for paired exchange surgeries with three weeks advance
- Must have laparoscopic donor surgical capability
The CHIP program helps patients without donors who are either children or are disadvantaged because they have high PRAs
- NKR member centers that have net chains started > 0 may enroll up to 50 candidates in the CHIP program
- Net chains started is the total number of chains that a center starts less the total number of chains a center ends
- CHIP candidates must be children (18 or younger) or sensitized adults
- The most likely blood types to find a CHIP match are "AB" and "A" blood types
Bridge Donor Guidelines
A bridge donor is any paired donor that donates after their recipient (i.e. friend or family member) receives a kidney transplant in a swap. The bridge donor serves as a "bridge" to the next cluster of transplants in a chain and generally has the ability to be with their friend or family member while they recover from transplant surgery, before they themselves go through kidney donation surgery. Bridge donor guidelines are as follows:
- Bridge donors should be prepared to donate between three weeks and three months of their paired recipient's surgery with no significant schedule limitations.
- Bridge donors must have no significant medical risks that could prohibit them from donating.
- The donor center must be confident that the bridge donor will follow through with donation.
- New member centers may want to complete at least three exchange transplants prior to identifying donors as bridge donor candidates.
- Member center guidelines for educating and evaluating donors to qualify to be bridge donor candidates should include:
- Discussions regarding the possibility of being a bridge donor should begin at initial donor evaluation and continue throughout the process.
- If there is any hesitation with the potential bridging donor, the center should decline offers to bridge the donor and identify the donor accordingly in the NKR donor profile.
- When asking a donor to bridge, an in-person discussion should occur and include the donor's support person.
- Member centers must maintain frequent contact with bridge donors.
- Member centers should advise bridge donor candidates to discuss their commitment to paired exchange with their employer early in the process and again when they become a bridge donor.
- Member centers must clarify any time constraints with bridge donor candidates and advise donors of the need for immediate notification of any unexpected travel plans and availability during that time for blood draws.
- Member centers should re-educate donors and reconfirm their availability prior to accepting the donor for a bridge position in a swap.
Help for Medicaid/MediCal Patients
Medicaid and MediCal patients are typically disadvantaged in paired exchange because
these insurance programs will generally not pay for out of state physician's fees which will
block matches with out of state donors. The best opportunity for Medicaid/MediCal patients
is to convert their insurance to Medicare. Below is a conversion guide.
- If the patient is on dialysis and has the requisite work history, then Medicare
enrollment is granted based on dialysis prior to transplant.
- If the patient is not on dialysis and has the requisite work history, then the center
should assist the patient with the process for Medicare enrollment at the time of
transplant and communicate a billing hold to current payor(s) until Medicare is
effective. Additionally, the donor center must agree to hold billing for all
professional fees until recipient's Medicare policy goes into effect (a billing hold is
better than billing and reimbursing the current payer and then rebilling Medicare).
- Member Centers must assist patients with obtaining documentation of Medicare entitlement
so that the center can complete a CMS Form 2728 Medical Evidence Report (MER) in order
to implement Medicare coverage.
- The recipient's Center must provide a completed CMS 2728 Form to the donor center upon
match offer acceptance.
- Medicare entitlement should always be confirmed prior to transplantation so that the
patient is aware of any potential out of pocket expenses, the need to choose RX coverage
and other related financial issues.
Click here to review a list of Kidney Transplant Centers.